Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures

Cell Motil Cytoskeleton. 1997;38(1):9-21. doi: 10.1002/(SICI)1097-0169(1997)38:1<9::AID-CM2>3.0.CO;2-4.


We sought components that function in morphogenetic events downstream from the segmentation pathway in Drosophila embryos, so we examined mutations that affect development of adult hairs and/or bristles to identify a subset that also affect hairs and denticles on the cuticle of first instar larvae. Mutations at 4 of 23 loci surveyed cause distinct abnormalities in these larval structures, and two other loci have more subtle, variable effects. In particular, forked and singed mutants produce complex, allele-specific phenotypes. These loci encode actin-associated proteins and, consistent with that information, mutations cause abnormalities in actin bundles that support nascent hairs and denticles in stage 14-16 embryos. We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / analysis
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cytoskeleton
  • Drosophila / cytology
  • Drosophila / embryology*
  • Drosophila Proteins*
  • Female
  • Genes, Insect / physiology
  • Insect Proteins / genetics
  • Insect Proteins / physiology*
  • Larva
  • Male
  • Microfilament Proteins / genetics
  • Microfilament Proteins / physiology*
  • Morphogenesis
  • Mutation
  • Phenotype


  • Actins
  • Carrier Proteins
  • Drosophila Proteins
  • Insect Proteins
  • Microfilament Proteins
  • f protein, Drosophila
  • fascin