Cryoanalgesia is commonly used by pain management specialists to alleviate painful nerve disorders of the back, face, and thoracic region. While cryogenic denervation results in pain relief, there is little to no incidence of neuritis or amputation-neuroma formation. The authors have used the Neurostat unit (Westco Medical Corporation), which was designed for cryogenic denervation of sensory and motor nerves, in the treatment of the intermetatarsal space neuroma. The authors present an overview of cryoanalgesic therapy, including a discussion of history, mechanism of action, indications, and description of the apparatus. The authors submit a case study of cryogenic denervation of the third intermetatarsal space.