Rel/NF-kappa B and I kappa B proteins: an overview

Semin Cancer Biol. 1997 Apr;8(2):63-73. doi: 10.1006/scbi.1997.0057.


Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • Humans
  • NF-kappa B* / chemistry
  • NF-kappa B* / genetics
  • NF-kappa B* / physiology
  • Protein Conformation
  • Proto-Oncogene Proteins* / chemistry
  • Proto-Oncogene Proteins* / genetics
  • Proto-Oncogene Proteins* / physiology
  • Structure-Activity Relationship
  • Transcription Factor RelB
  • Transcription Factors


  • DNA-Binding Proteins
  • NF-kappa B
  • Proto-Oncogene Proteins
  • RELB protein, human
  • Transcription Factors
  • Transcription Factor RelB