Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084

Acta Neurol Scand. 1997 Sep;96(3):171-3. doi: 10.1111/j.1600-0404.1997.tb00262.x.


Introduction: Migraine is a genetic heterogeneous disorder. The 11084 A to G base substitution is in the gene for the ND4 subunit of the respiratory complex I, and leads to a Thr to Ala amino acid replacement. This mutation had been found in 25% of Japanese migraineurs, while tension-type headache sufferers and non-migraineurs did not have it.

Material and methods: We investigated the importance of this mutation in Danish migraineurs without aura, migraineurs with aura and non-migraineurs from the general population.

Results: We did not detect this mutation in Danes.

Conclusion: Our result excludes a significant role of this mutation in the etiology of migraine in Denmark, and its absence in non-migraineurs supports that this mutation is rare in non-Japanese populations.

MeSH terms

  • Adult
  • Base Composition / genetics
  • DNA Mutational Analysis*
  • DNA, Mitochondrial / genetics*
  • Denmark
  • Female
  • Genetics, Population
  • Humans
  • Male
  • Migraine Disorders / genetics*
  • Nucleotide Mapping
  • Polymerase Chain Reaction


  • DNA, Mitochondrial