Cerebrospinal fluid apo E and apo A-I concentrations in early- and late-onset Alzheimer's disease

Neurosci Lett. 1997 Aug 15;231(3):175-8. doi: 10.1016/s0304-3940(97)00558-2.


We compared cerebrospinal fluid (CSF) apolipoprotein (apo) A-I and apo E concentrations in early- and late-onset Alzheimer's disease (EOAD (n = 11), LOAD (n = 15), respectively) with those in control subjects (n = 23). CSF apo A-I levels in both EOAD and LOAD were consistent with control subjects. However, CSF apo E levels were significantly lower in EOAD group (mean +/- SD; 2.65 +/- 1.69 mg/l, P < 0.05) and higher in LOAD group (5.90 +/- 1.94 mg/l, P < 0.01) than those in control group (4.16 +/- 1.69 mg/l). In addition, the epsilon4 allele frequency was not different between EOAD and LOAD groups. Although the reason for the difference in CSF apo E concentrations between two groups is unknown, CSF apo E concentration seems to be associated with the pathogenesis of EOAD and LOAD. The rate of apo E production and/or catabolism in the brain may be different between them.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / cerebrospinal fluid*
  • Alzheimer Disease / genetics
  • Apolipoprotein A-I / cerebrospinal fluid*
  • Apolipoproteins E / cerebrospinal fluid*
  • Apolipoproteins E / genetics
  • Female
  • Humans
  • Male
  • Middle Aged


  • Apolipoprotein A-I
  • Apolipoproteins E