PHAS/4E-BPs as Regulators of mRNA Translation and Cell Proliferation

Trends Biochem Sci. 1997 Sep;22(9):345-9. doi: 10.1016/s0968-0004(97)01101-8.

Abstract

Insulin and growth factors elicit rapid increases in protein synthesis by stimulating mRNA translation. PHAS/4E-BPs, a recently discovered family of elF4E-binding, proteins, appear to play a key role in this process, as well as in the control of cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins*
  • Cell Division / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Phosphoproteins / genetics
  • Phosphoproteins / physiology*
  • Phosphorylation
  • Protein Biosynthesis
  • RNA, Messenger / genetics*
  • Rats
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • EIF4EBP1 protein, human
  • Eif4ebp1 protein, rat
  • Intracellular Signaling Peptides and Proteins
  • Phosphoproteins
  • RNA, Messenger

Associated data

  • SWISSPROT/L36055
  • SWISSPROT/L36056
  • SWISSPROT/U05014
  • SWISSPROT/U75530