PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

Trends Biochem Sci. 1997 Sep;22(9):355-8. doi: 10.1016/s0968-0004(97)01097-9.


PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.

Publication types

  • Review

MeSH terms

  • Cell Survival / physiology
  • Humans
  • Models, Biological
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • Phosphotransferases / metabolism
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-akt


  • Proto-Oncogene Proteins
  • Phosphotransferases
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • AKT1 protein, human
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt