Effect of booster vaccination with a multivalent clostridial bacterin-toxoid on sudden death syndrome mortality rate among feedlot cattle

J Am Vet Med Assoc. 1997 Sep 15;211(6):749-53.

Abstract

Objective: To determine whether booster vaccination with a multivalent clostridial bacterin-toxoid would affect the sudden death syndrome (SDS) mortality rate among feedlot cattle.

Design: Field trial.

Animals: 83, 115 cattle at a Nebraska feedlot.

Procedure: Cattle arriving at the feedlot underwent routine processing according to established protocol. All cattle received a sequentially numbered ear tag and a 2-ml dose of a multivalent bacterin-toxoid designed to protect cattle against Clostridium chauvoei, C speticum, C novyi, C sordellii, and C perfringens types C and D. Approximately 90 days prior to slaughter, growth promotants were implanted in all cattle, and cattle were allocated to a treatment or control group on the basis of the last digits of their ear tag numbers. Cattle in the treatment group received a second 2-ml dose of clostridial bacterintoxoid; control cattle did not.

Results: Significant differences between groups in regard to crude, feeding pen, or SDS mortality rates were not detected. Sudden death syndrome mortality rate across both groups was 0.24%. If the SDS mortality rate in midwestern feedlot cattle was reduced > or = 40% by booster vaccination with a multivalent clostridial bacterin-toxoid, this experiment included enough animals to have a 90% probability of detecting that difference.

Clinical implications: Booster vaccination with a multivalent clostridial bacterin-toxoid does not affect SDS mortality rate among feedlot cattle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Bacterial / immunology
  • Bacterial Vaccines / administration & dosage*
  • Bacterial Vaccines / immunology
  • Cattle
  • Cattle Diseases / epidemiology
  • Cattle Diseases / immunology
  • Cattle Diseases / mortality*
  • Clostridium / immunology*
  • Clostridium / metabolism
  • Clostridium Infections / immunology
  • Clostridium Infections / mortality
  • Clostridium Infections / veterinary*
  • Cost-Benefit Analysis
  • Death, Sudden / etiology
  • Death, Sudden / veterinary*
  • Dose-Response Relationship, Drug
  • Immunization, Secondary / economics
  • Immunization, Secondary / veterinary*
  • Nebraska / epidemiology
  • Syndrome
  • Toxoids / immunology
  • Toxoids / pharmacology*
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology

Substances

  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Toxoids
  • Vaccines, Inactivated