Centrally administered choline increases plasma prolactin levels in conscious rats

Neurosci Lett. 1997 Aug 29;232(2):79-82. doi: 10.1016/s0304-3940(97)00580-6.

Abstract

Intracerebroventricular (i.c.v.) administration of choline, a precursor of acetylcholine (ACh) increased plasma prolactin levels in a time and dose-dependent manner in conscious rats. Pretreatment of rats with the cholinergic muscarinic antagonist, atropine (10 microg, i.c.v.), blocked the increase in plasma prolactin level. The increase was not influenced by pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 microg, i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 microg, i.c.v.), a high affinity choline uptake inhibitor, attenuated the choline-induced increase of plasma prolactin levels. These results show that choline increases plasma prolactin levels by activating muscarinic receptors via presynaptic mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atropine / pharmacology
  • Choline / administration & dosage*
  • Cholinergic Agents / pharmacology
  • Dose-Response Relationship, Drug
  • Hemicholinium 3 / pharmacology
  • Injections, Intraventricular
  • Male
  • Mecamylamine / pharmacology
  • Muscarinic Antagonists / pharmacology
  • Nicotinic Antagonists / pharmacology
  • Prolactin / blood*
  • Prolactin / drug effects
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Cholinergic Agents
  • Muscarinic Antagonists
  • Nicotinic Antagonists
  • Hemicholinium 3
  • Mecamylamine
  • Atropine
  • Prolactin
  • Choline