Silicone granulomatous lymphadenopathy and siliconomas of the breast

Histol Histopathol. 1997 Oct;12(4):1003-11.


In the present study, two histologically-distinct cases of granulomatous lymphadenitis induced by dimethylpolysiloxane (silicone polymer) implants were studied. Four and six years after implant, and following surgery for breast cancer, painful homolateral axillary adenopathies were observed and biopsied. In both cases, histological examination led to a diagnosis of "silicone-induced granulomatous adenitis" requiring removal of implants. Foreign-body granulomas (siliconomas) were observed in surrounding tissue with no apparent rupture of implant capsules; however, visible retraction, hardening and scattered calcifications were noted. The presence of silica was revealed by incineration of a number of biopsied lymph nodes, a technique not hitherto used in the study of this pathology. A review is offered of the literature available.

MeSH terms

  • Breast / pathology*
  • Breast Implants / adverse effects*
  • Female
  • Granuloma, Foreign-Body / chemically induced
  • Granuloma, Foreign-Body / pathology*
  • Humans
  • Immunoblastic Lymphadenopathy / chemically induced
  • Immunoblastic Lymphadenopathy / pathology*
  • Lymph Nodes / pathology
  • Middle Aged
  • Silicon / adverse effects*


  • Silicon