Mucosal interleukin-1 beta production and acid secretion in enlarged fold gastritis

Aliment Pharmacol Ther. 1997 Aug;11(4):801-9. doi: 10.1046/j.1365-2036.1997.00200.x.


Background: We have previously shown that eradication of Helicobacter pylori increases acid secretion in H. pylori-associated enlarged fold gastritis.

Aim: To investigate whether locally produced interleukin-1 beta is possibly involved in the inhibition of acid secretion in H. pylori gastritis.

Methods: IL-1 beta release from the gastric body mucosa was determined by short-term culture of biopsy specimens in 13 patients with enlarged fold gastritis (all H. pylori-positive), five H. pylori-positive and 10 H. pylori-negative patients without enlarged folds. The acid-inhibitory effect of locally produced IL-1 beta was examined by [14C]-aminopyrine uptake assay using isolated rabbit gastric glands.

Results: IL-1 beta release was significantly greater in patients with enlarged fold gastritis, significantly correlated with both basal and tetragastrin-stimulated acid outputs in the H. pylori-positive patients (r = -0.591 and r = -0.641, respectively; P < 0.01), and significantly decreased with concomitant increases in acid secretions after eradication of H. pylori. [14C]-aminopyrine uptake was inhibited by IL-1 beta in a dose-dependent manner.

Conclusions: Increased production of IL-1 beta caused by H. pylori infection is possibly involved in the inhibition of acid secretion in enlarged fold gastritis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aminopyrine / metabolism
  • Animals
  • Female
  • Gastric Acid / metabolism*
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism*
  • Gastrins / blood
  • Gastritis, Hypertrophic / metabolism*
  • Gastritis, Hypertrophic / pathology
  • Helicobacter Infections / metabolism*
  • Helicobacter pylori*
  • Humans
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / pharmacology
  • Male
  • Middle Aged
  • Rabbits
  • Stomach / pathology


  • Gastrins
  • Interleukin-1
  • Aminopyrine