Hypertension, aging, and atherosclerosis. The endothelial interface

Med Clin North Am. 1997 Sep;81(5):1231-40. doi: 10.1016/s0025-7125(05)70576-9.


Hypertension, atherosclerosis, and aging are considered major independent risk factors for cardiovascular morbidity and mortality. Although independent as risk factors, the three entities are closely related and often operate simultaneously to affect the cardiovascular system adversely, resulting in damage to various organs. This article evaluates the evidence that endothelial damage may be the underlying pathophysiologic mechanism that connects the three entities.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Arteriosclerosis / complications
  • Arteriosclerosis / physiopathology*
  • Blood Pressure / drug effects
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / mortality
  • Endothelium, Vascular / physiology*
  • Humans
  • Hypertension / complications
  • Hypertension / physiopathology*
  • Nitric Oxide / biosynthesis
  • Nitric Oxide / metabolism
  • Nitric Oxide / physiology*


  • Nitric Oxide