Armadillo and dTCF: A Marriage Made in the Nucleus

Curr Opin Genet Dev. 1997 Aug;7(4):459-66. doi: 10.1016/s0959-437x(97)80071-8.

Abstract

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Armadillo Domain Proteins
  • Cell Adhesion
  • Cell Movement
  • Cytoskeletal Proteins / metabolism
  • DNA-Binding Proteins / metabolism*
  • Drosophila / genetics
  • Drosophila / growth & development
  • Drosophila Proteins*
  • Gene Expression Regulation, Developmental
  • Insect Proteins / metabolism*
  • Lymphoid Enhancer-Binding Factor 1
  • Protein Binding
  • Signal Transduction
  • Trans-Activators*
  • Transcription Factors / metabolism*
  • beta Catenin

Substances

  • ARM protein, Drosophila
  • Armadillo Domain Proteins
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Insect Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Trans-Activators
  • Transcription Factors
  • beta Catenin