From receptor to nucleus: the Smad pathway

Curr Opin Genet Dev. 1997 Aug;7(4):467-73. doi: 10.1016/s0959-437x(97)80072-x.


The transforming growth factor-beta (TGF-beta) superfamily plays a central role in the specification and patterning of cells in the early embryo. Several years ago, the TGF-beta s were shown to signal through serine/threonine receptor kinases. Now, with the identification of Smad proteins, we can trace the TGF-beta signal transduction pathway from the receptors into the nucleus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Body Patterning
  • DNA-Binding Proteins / metabolism*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism
  • Receptors, Transforming Growth Factor beta / metabolism*
  • Signal Transduction
  • Smad2 Protein
  • Trans-Activators*
  • Transforming Growth Factor beta / metabolism


  • DNA-Binding Proteins
  • Receptors, Transforming Growth Factor beta
  • Smad2 Protein
  • Trans-Activators
  • Transforming Growth Factor beta
  • Protein Serine-Threonine Kinases