Limb mutants: what can they tell us about normal limb development?

Curr Opin Genet Dev. 1997 Aug;7(4):530-6. doi: 10.1016/s0959-437x(97)80082-2.

Abstract

Classical mutations and those that derive from gene targeting have provided an important resource to explore the molecular control of vertebrate limb development. Recent studies have combined molecular analysis of limb mutants with embryological approaches to understand the regulation of limb patterning and growth.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Extremities / embryology*
  • Gene Expression Regulation, Developmental
  • Mutation*