Notch signalling in development: on equivalence groups and asymmetric developmental potential

Curr Opin Genet Dev. 1997 Aug;7(4):537-42. doi: 10.1016/s0959-437x(97)80083-4.


Notch-mediated lateral signalling takes place between equivalent cells that then adopt alternative fates. An example is the epidermal-neural choice in the Drosophila neuro-ectoderm. Sometimes this choice is random. Sometimes it is biased to a preferred cell by an extrinsic signal. Sometimes the neural precursor is predetermined. A stochastic outcome is probably older in evolutionary terms.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage / genetics
  • Drosophila / cytology
  • Drosophila / embryology
  • Drosophila / genetics
  • Drosophila Proteins
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Nervous System / embryology
  • Receptors, Notch
  • Signal Transduction*


  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch