Ageing: effects on oxidative function of skeletal muscle in vivo

Mol Cell Biochem. 1997 Sep;174(1-2):321-4.


31P magnetic resonance spectroscopy studies were carried out on calf muscle of 144 normal male and female subjects age 20-83 years in order to investigate age-related changes in muscle metabolism. Compared to the young adults (20-29 years), oxidative capacity was higher in the children (6-12 years) and was significantly decreased in the elderly (70-83 years). In the adults, the intracellular pH change during exercise diminished with increasing age, resulting in higher calculated free [ADP] and possibly serving as an adaptive mechanism to stimulate mitochondrial ATP production. Children also had higher pH and [ADP] in exercise, but unlike results from the elderly, this was associated with higher oxidative capacity and more rapid metabolic recovery from exercise.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / metabolism*
  • Adenosine Triphosphate / metabolism*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Child
  • Exercise
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / metabolism*
  • Oxidation-Reduction
  • Sex Factors


  • Adenosine Diphosphate
  • Adenosine Triphosphate