Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction

Pathol Int. 1997 Sep;47(9):642-6. doi: 10.1111/j.1440-1827.1997.tb04556.x.


A rare case of dedifferentiated liposarcoma (well-differentiated liposarcoma with an inflammatory malignant fibrous histiocytoma (MFH)-like anaplastic component) occurring in a 69-year-old male is presented. The patient had noticed a dull pain in his left loin and thigh for about 1 month. Computed tomography examination revealed a low-density mass lesion, measuring about 6 cm in diameter, in the left iliopsoas muscle, and it was surgically removed. Grossly, the lesion was composed of an encapsulated, soft, whitish mass and an adjacent, well-demarcated, yellowish hard nodule, measuring about 2.5 cm in diameter. Microscopically, both lesions showed features of an inflammatory variant of MFH and a sclerosing type of well-differentiated liposarcoma, respectively. To our knowledge, only two cases of dedifferentiated liposarcoma combined with inflammatory MFH as a dedifferentiated component have been recorded in the literature. The salient feature of the present case is a systemic inflammatory reaction, as shown by prominent leukocytosis (up to 73,900/mm3) and the elevated serum value of C reactive protein (up to 26.0 mg/dL), which were transiently reduced after surgery. The inflammatory reaction was suggested to be induced by cytokines, such as granulocyte colony-stimulating factor and interleukin-6, which were probably produced by the tumor cells in the present case, because the elevated serum values of those cytokines were decreased after surgery.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • C-Reactive Protein / analysis
  • Fatal Outcome
  • Granulocyte Colony-Stimulating Factor / blood
  • Histiocytoma, Benign Fibrous / chemistry
  • Histiocytoma, Benign Fibrous / pathology*
  • Humans
  • Immunohistochemistry
  • Interleukin-6 / blood
  • Leukemoid Reaction / pathology*
  • Liposarcoma / chemistry
  • Liposarcoma / pathology*
  • Male
  • Muscle Neoplasms / chemistry
  • Muscle Neoplasms / pathology*
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor
  • Interleukin-6
  • Granulocyte Colony-Stimulating Factor
  • C-Reactive Protein