Abstract
The possibility of plasmid-encoded quinolone resistance is explored in two model systems. In the first, increasing amounts of wild-type gyrA allele moderately increased minimum inhibitory concentrations to quinolone antibiotics. In the second model, a mutant gyrA allele encoded by a multicopy plasmid produced a quinolone resistance phenotype upon its expression in a quinolone-susceptible Escherichia coli strain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Anti-Infective Agents / pharmacology*
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DNA Gyrase
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DNA Topoisomerases, Type II / genetics
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Drug Resistance, Microbial / genetics*
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Fluoroquinolones
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Gene Dosage
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Genetic Complementation Test
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Plasmids*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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DNA Gyrase
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DNA Topoisomerases, Type II