Abstract
Some simple geiparvarin analogues, in which the coumarin moiety has been replaced with an X-substituted benzene ring, are described. The compounds were tested on LoVo cells (human colon carcinoma cell line) and some of them show a cytotoxicity comparable with that of the prototype. A QSAR analysis was also attempted, but it did not provide satisfactory results, mainly because of the limited range of variation of the biological activity.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Colonic Neoplasms / pathology
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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geiparvarin