Histone Acetylation in Chromatin Structure and Transcription

Nature. 1997 Sep 25;389(6649):349-52. doi: 10.1038/38664.

Abstract

'The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle. These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism
  • Chromatin / physiology*
  • Forecasting
  • Gene Expression Regulation / physiology
  • Heterochromatin / physiology
  • Histones / metabolism
  • Histones / physiology*
  • Humans
  • Protein Conformation*
  • Transcription, Genetic*

Substances

  • Chromatin
  • Heterochromatin
  • Histones