Isoprostane 8-epi-prostaglandin F2 alpha is a potent contractor of human peripheral lymphatics

Lymphology. 1997 Sep;30(3):155-9.


Isoprostanes are products of free radical-catalyzed peroxidation and 8-epi-prostaglandin (PG) F2 alpha is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF2 alpha stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE1, 8-epi-PGE2) had only limited lymphatic contractile potency. These data suggest a potentially relevant role for epi-8-PGF2 alpha in facilitating lymph transport especially in conditions of inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • Adolescent
  • Adult
  • Dinoprost / analogs & derivatives*
  • Dinoprost / pharmacology
  • Female
  • Humans
  • Lymphatic System / drug effects*
  • Male
  • Middle Aged
  • Prostaglandin Endoperoxides, Synthetic / pharmacology
  • Thromboxane A2 / analogs & derivatives
  • Thromboxane A2 / pharmacology
  • Vasoconstrictor Agents / pharmacology*


  • Prostaglandin Endoperoxides, Synthetic
  • Vasoconstrictor Agents
  • 8-epi-prostaglandin F2alpha
  • Thromboxane A2
  • 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
  • Dinoprost