Antinociception induced by verapamil and chloramphenicol in mice

Biol Neonate. 1997;72(1):28-31. doi: 10.1159/000244463.

Abstract

The analgesic effects of verapamil, a calcium channel blocker, and chloramphenicol, a phenicolated antibiotic, were compared using the test of acetic-acid-induced writhing and the hot-plate test in mice. The results suggest that both drugs have antinociceptive properties comparable to salicylate analgesia. No significant difference was found between verapamil- and chloramphenicol-induced analgesia (p < 0.05).

Publication types

  • Comparative Study

MeSH terms

  • Analgesia / methods*
  • Analgesics / pharmacology*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Calcium Channel Blockers / pharmacology*
  • Chloramphenicol / pharmacology*
  • Female
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Pain Measurement / methods
  • Verapamil / pharmacology*

Substances

  • Analgesics
  • Anti-Bacterial Agents
  • Calcium Channel Blockers
  • Chloramphenicol
  • Verapamil