Pharmacokinetic profile of cefaclor

Int J Clin Pharmacol Ther. 1997 Sep;35(9):374-80.

Abstract

Cefaclor is a well-absorbed oral cephalosporin antibiotic. Peak concentrations in serum are attained within 30-60 minutes. Food intake reduces the rate, but not the extent of absorption. Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours. Most of the drug is excreted unchanged in the urine, the serum half-life after oral administration is 0.5-0.7 hours. Due to the chemical degradation, cefaclor does not accumulate to the same degree as other cephalosporins in case of renal impairment.

Publication types

  • Review

MeSH terms

  • Aged
  • Antacids / pharmacology
  • Area Under Curve
  • Cefaclor / metabolism
  • Cefaclor / pharmacokinetics*
  • Cephalosporins / pharmacokinetics*
  • Child
  • Cimetidine / pharmacology
  • Drug Interactions
  • Half-Life
  • Humans
  • Infant
  • Renal Insufficiency / metabolism
  • Theophylline / pharmacology

Substances

  • Antacids
  • Cephalosporins
  • Cefaclor
  • Cimetidine
  • Theophylline