Intravenous cyclosporine therapy in the treatment of pyoderma gangrenosum secondary to Crohn's disease

Cutis. 1997 Sep;60(3):135-8.


Pyoderma gangrenosum is a destructive, ulcerative skin condition often associated with systemic illnesses such as inflammatory bowel disease, myeloproliferative disorders, and the inflammatory arthritides. We present a patient with long-standing pyoderma gangrenosum associated with Crohn's disease. Multiple deep leg ulcerations were unresponsive over the course of several years to treatment with azathioprine, systemic corticosteroids, 6-mercaptopurine, and dapsone. The patient was hospitalized and treated with a ten-day course of intravenous cyclosporine therapy followed by outpatient oral cyclosporine and showed significant improvement.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Crohn Disease / complications*
  • Cyclosporine / administration & dosage
  • Cyclosporine / therapeutic use*
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / therapeutic use*
  • Infusions, Intravenous
  • Pyoderma Gangrenosum / drug therapy*
  • Pyoderma Gangrenosum / etiology*
  • Pyoderma Gangrenosum / physiopathology
  • Wound Healing / drug effects


  • Immunosuppressive Agents
  • Cyclosporine