Simplifying the evaluation of postprandial antral motor function in patients with suspected gastroparesis

Am J Gastroenterol. 1997 Sep;92(9):1496-500.

Abstract

Objectives: Antral hypomotility is associated with symptoms of gastric stasis[fnc,1.

Aims: To quantitate antral motor function in patients with suspected gastroparesis due to idiopathic or secondary hypomotility; and to determine whether there are simpler indices to assess antral motility.

Methods: Standard eight-lumen antroduodenal manometry was performed in 67 patients for 3-h fasting and 2-h postprandial measurements. Antral motility 1 cm proximal to the pylorus was quantitated for a 2-h fed period as an index: MI = ln[(number contractions x (amplitudes) + 1]. Fifteen healthy volunteers served as controls.

Results: Forty-one patients had hypomotility and 26 normal antral motility, defined by a MI > or = 13.67. Patients with antral hypomotility due to a neuropathic (n = 17) or myopathic (n = 3) disorder showed a significantly lower MI (11.6 +/- 0.3 [SEM]; 95% confidence interval 11-12.1) compared with patients with idiopathic hypomotility (n = 21, MI = 12.5 +/- 0.2). There were fewer antral contractions postprandially in patients with secondary hypomotility than in idiopathic hypomotility (66 +/- 6 per 2 h vs 90 +/- 10; p < 0.05), and both were lower than in healthy controls (224 +/- 15). Mean amplitudes of antral contractions were similar for the neuropathic, idiopathic and control groups, but lower in myopathic (33 +/- 6 mm Hg) compared with neuropathic disorders (48 +/- 4 mm Hg; fifth percentile 30.6 mm Hg).

Conclusions: An antral MI < 12.1 should lead to a search for an underlying neuropathic or myopathic process; an average of less than 1 contraction per minute postprandially is a simple estimate of significant hypomotility. Antral contractions with a mean amplitude < 30 mm Hg suggest a myopathic disorder.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autonomic Nervous System Diseases / complications
  • Colonic Diseases, Functional / complications
  • Confidence Intervals
  • Diabetes Complications
  • Digestion / physiology*
  • Duodenum / physiopathology
  • Dyspepsia / complications
  • Eating / physiology*
  • Evaluation Studies as Topic
  • Fasting / physiology
  • Female
  • Gastric Emptying / physiology
  • Gastrointestinal Motility / physiology*
  • Gastroparesis / etiology
  • Gastroparesis / physiopathology*
  • Humans
  • Male
  • Manometry
  • Middle Aged
  • Muscular Diseases / complications
  • Nervous System Diseases / complications
  • Peristalsis / physiology
  • Pressure
  • Pyloric Antrum / physiology*
  • Pylorus / physiopathology