Pax-2 in the chiasm

Cell Tissue Res. 1997 Nov;290(2):197-200. doi: 10.1007/s004410050923.


Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axonal Transport
  • Axons / physiology*
  • DNA-Binding Proteins / physiology*
  • Humans
  • Mice
  • Nervous System Physiological Phenomena
  • Optic Chiasm / physiology*
  • PAX2 Transcription Factor
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • PAX2 Transcription Factor
  • PAX2 protein, human
  • Pax2 protein, mouse
  • Transcription Factors