Inhibitor of protein tyrosine kinase, radicicol, suppresses the expression of cyclooxygenase and pro-inflammatory cytokines in LPS-stimulated rat alveolar macrophage in part by accelerating degradation of mRNA

Adv Exp Med Biol. 1997:407:281-8. doi: 10.1007/978-1-4899-1813-0_42.
No abstract available

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors / pharmacology*
  • Enzyme Induction / drug effects
  • Enzyme Inhibitors / pharmacology*
  • Interleukin-1 / biosynthesis
  • Interleukin-1 / genetics
  • Isoenzymes / biosynthesis
  • Isoenzymes / genetics
  • Lactones / pharmacology*
  • Lipopolysaccharides / pharmacology*
  • Macrolides
  • Macrophages, Alveolar / drug effects*
  • Macrophages, Alveolar / metabolism
  • Phosphorylation / drug effects
  • Prostaglandin-Endoperoxide Synthases / biosynthesis
  • Prostaglandin-Endoperoxide Synthases / genetics
  • Protein Processing, Post-Translational / drug effects*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Ribonucleases / metabolism*
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Tumor Necrosis Factor-alpha / genetics
  • src-Family Kinases / metabolism

Substances

  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Enzyme Inhibitors
  • Interleukin-1
  • Isoenzymes
  • Lactones
  • Lipopolysaccharides
  • Macrolides
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Protein-Tyrosine Kinases
  • src-Family Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Ribonucleases
  • monorden