Quantitative evaluation of the hepatic functional reserve using technetium-99m DTPA-galactosyl human serum albumin before and after transjugular intrahepatic portosystemic shunt

Eur J Nucl Med. 1997 Oct;24(10):1268-72. doi: 10.1007/s002590050151.


Transjugular intrahepatic portosystemic shunt (TIPS), a new therapeutic method, has been performed widely for the treatment of portal hypertension. TIPS produces a decrease in the portal blood flow to the hepatic parenchyma, which is considered to cause a reduction in hepatic functional reserve. To evaluate the changes in hepatic functional reserve after TIPS, we performed technetium-99m DTPA-galactosyl human serum algumin (99mTc-GSA) hepatic scintigraphy before and after TIPS in eight male patients, ranging in age from 54 to 72 years (mean 62.2 years). Two quantitative indices - blood clearance index (uptake ratio of the heart at 15 min to that at 3 min, HH15) and hepatic accumulation index (uptake ratio of the liver to the liver plus heart at 15 min, LHL15) - were calculated from the time-activity curves of the heart and liver. Early and late uptake constant indices (early and late KU) were also calculated from the time-activity curves of the heart and liver by means of Patlak plot. The values of HH15, LHL15 and late KU deteriorated after TIPS in all patients. Early KU (1-3 min) decreased by more than 55% in two patients who showed a poor prognosis and corresponded well with the status of the portosystemic shunt. It is concluded that 99mTc-GSA hepatic scintigraphy is a useful means of evaluating the degree to which hepatic function is compromised following TIPS. The post-TIPS alterations in HH15, LHL15 and late KU (5-10 min) reflect the changes in hepatic functional reserve, and early KU is a useful index for evaluating the degree of portosystemic shunt.

MeSH terms

  • Humans
  • Hypertension, Portal / diagnostic imaging*
  • Hypertension, Portal / physiopathology
  • Hypertension, Portal / surgery
  • Liver / diagnostic imaging*
  • Liver Circulation / physiology
  • Male
  • Middle Aged
  • Portasystemic Shunt, Transjugular Intrahepatic*
  • Radionuclide Imaging
  • Technetium Tc 99m Aggregated Albumin*
  • Technetium Tc 99m Pentetate*


  • Technetium Tc 99m Aggregated Albumin
  • technetium Tc 99m DTPA-galactosyl-human serum albumin
  • Technetium Tc 99m Pentetate