Abstract
This report describes a neonate with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis attributed to inadequate breastfeeding and severe dehydration. Dialytic and general supportive care, together with concurrent anticoagulation, and continuous aggressive intrathrombic instillation of urokinase for 5 days resulted in near-complete thrombolysis. Renal functional recovery began 11 days after the onset of anuria. Despite ischemic atrophy of the left kidney, renal function and blood pressure were normal on follow-up. Thus, in neonates thrombolytic therapy may positively impact survival and recovery of renal function even in the setting of prolonged ischemic renal injury.
MeSH terms
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Aortic Diseases / complications
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Aortic Diseases / diagnostic imaging
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Aortic Diseases / drug therapy*
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Aortography
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Fibrinolytic Agents / administration & dosage
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Fibrinolytic Agents / therapeutic use
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Heparin / administration & dosage
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Heparin / therapeutic use
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Humans
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Infant, Newborn
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Infusions, Intravenous
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Male
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Renal Artery Obstruction / complications
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Renal Artery Obstruction / diagnostic imaging
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Renal Artery Obstruction / drug therapy*
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Renal Dialysis
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Thrombolytic Therapy*
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Thrombosis / complications
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Thrombosis / diagnostic imaging
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Thrombosis / drug therapy*
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Urokinase-Type Plasminogen Activator / administration & dosage
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Urokinase-Type Plasminogen Activator / therapeutic use
Substances
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Fibrinolytic Agents
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Heparin
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Urokinase-Type Plasminogen Activator