Neuroendocrine challenge studies of suicidal behavior

Psychiatr Clin North Am. 1997 Sep;20(3):563-79. doi: 10.1016/s0193-953x(05)70330-0.

Abstract

This article reviews the research data regarding human neuroendocrine systems and suicidal behavior. Special emphasis is placed on pharmacochallenge studies. Such studies uniquely allow for functional assessment of neuroendocrine parameters in living subjects. Serotonergic mechanisms have been the most fruitful areas of research. While discussing the major areas of controversy, theoretical approaches to integration are offered.

Publication types

  • Review

MeSH terms

  • Depressive Disorder / diagnosis
  • Depressive Disorder / physiopathology*
  • Depressive Disorder / psychology
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology*
  • Neurotransmitter Agents / physiology*
  • Pituitary-Adrenal System / physiopathology*
  • Serotonin / physiology
  • Suicide / psychology*
  • Suicide Prevention
  • Suicide, Attempted / prevention & control
  • Suicide, Attempted / psychology*

Substances

  • Neurotransmitter Agents
  • Serotonin