Abstract
This article reviews the research data regarding human neuroendocrine systems and suicidal behavior. Special emphasis is placed on pharmacochallenge studies. Such studies uniquely allow for functional assessment of neuroendocrine parameters in living subjects. Serotonergic mechanisms have been the most fruitful areas of research. While discussing the major areas of controversy, theoretical approaches to integration are offered.
MeSH terms
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Depressive Disorder / diagnosis
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Depressive Disorder / physiopathology*
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Depressive Disorder / psychology
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Humans
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Hypothalamo-Hypophyseal System / physiopathology*
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Neurotransmitter Agents / physiology*
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Pituitary-Adrenal System / physiopathology*
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Serotonin / physiology
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Suicide / psychology*
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Suicide Prevention
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Suicide, Attempted / prevention & control
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Suicide, Attempted / psychology*
Substances
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Neurotransmitter Agents
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Serotonin