[The effect of thymogen on the heart in ischemia and reperfusion]

Eksp Klin Farmakol. 1997 May-Jun;60(3):27-9.
[Article in Russian]

Abstract

The anti-ischemic properties of thymogen were studied on an isolated heart model. Its cardioprotective effect was higher than that of dalargin and verapamil. The mechanism of the thymogen anti-ischemic action is realized without the participation of the opiate receptors and blockade of calcium entrance into the cardiomyocytes.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Arrhythmia Agents / pharmacology*
  • Anti-Arrhythmia Agents / therapeutic use
  • Calcium / metabolism
  • Dipeptides*
  • Enkephalin, Leucine-2-Alanine / analogs & derivatives
  • Enkephalin, Leucine-2-Alanine / metabolism
  • Enkephalin, Leucine-2-Alanine / pharmacology
  • Heart / drug effects*
  • In Vitro Techniques
  • Magnesium / metabolism
  • Myocardial Contraction / drug effects
  • Myocardial Ischemia / drug therapy*
  • Myocardial Reperfusion Injury / drug therapy*
  • Myocardium / cytology
  • Myocardium / pathology
  • Myoglobin / metabolism
  • Naloxone / metabolism
  • Naloxone / pharmacology
  • Narcotic Antagonists / metabolism
  • Narcotic Antagonists / pharmacology
  • Peptides / metabolism
  • Peptides / pharmacology*
  • Peptides / therapeutic use
  • Rats
  • Verapamil / metabolism
  • Verapamil / pharmacology

Substances

  • Anti-Arrhythmia Agents
  • Dipeptides
  • Myoglobin
  • Narcotic Antagonists
  • Peptides
  • thymogen
  • Naloxone
  • Enkephalin, Leucine-2-Alanine
  • Verapamil
  • Magnesium
  • Calcium
  • enkephalin-Leu, Ala(2)-Arg(6)-