Abstract
The anti-ischemic properties of thymogen were studied on an isolated heart model. Its cardioprotective effect was higher than that of dalargin and verapamil. The mechanism of the thymogen anti-ischemic action is realized without the participation of the opiate receptors and blockade of calcium entrance into the cardiomyocytes.
MeSH terms
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Animals
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Anti-Arrhythmia Agents / pharmacology*
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Anti-Arrhythmia Agents / therapeutic use
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Calcium / metabolism
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Dipeptides*
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Enkephalin, Leucine-2-Alanine / analogs & derivatives
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Enkephalin, Leucine-2-Alanine / metabolism
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Enkephalin, Leucine-2-Alanine / pharmacology
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Heart / drug effects*
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In Vitro Techniques
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Magnesium / metabolism
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Myocardial Contraction / drug effects
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Myocardial Ischemia / drug therapy*
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Myocardial Reperfusion Injury / drug therapy*
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Myocardium / cytology
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Myocardium / pathology
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Myoglobin / metabolism
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Naloxone / metabolism
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Naloxone / pharmacology
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Narcotic Antagonists / metabolism
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Narcotic Antagonists / pharmacology
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Peptides / metabolism
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Peptides / pharmacology*
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Peptides / therapeutic use
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Rats
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Verapamil / metabolism
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Verapamil / pharmacology
Substances
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Anti-Arrhythmia Agents
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Dipeptides
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Myoglobin
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Narcotic Antagonists
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Peptides
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thymogen
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Naloxone
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Enkephalin, Leucine-2-Alanine
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Verapamil
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Magnesium
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Calcium
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enkephalin-Leu, Ala(2)-Arg(6)-