Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease

Cytokine. 1997 Sep;9(9):711-6. doi: 10.1006/cyto.1997.0215.


Plasma levels of interleukin 12 (IL-12), a cytokine consisting of two different polypeptide subunits (p40 and p35), were measured together with interferon gamma (IFN-gamma) and other cytokines in 46 children with septic shock and purpura. The median (range) plasma IL-12 p40 level on admission was 457 (244-2677) pg/ml in non-survivors vs 189 (< 40-521) pg/ml in survivors (P = < 0.001). IL-12 p70 levels were elevated in only nine patients. IL-12 p40 plasma levels were positively correlated with tumour necrosis factor alpha (TNF-alpha), IL-6, IL-8, IL-10 and PRISM-score, whereas they were negatively correlated with C-reactive protein (CRP), whole blood cell (WBC) and serum glucose levels. Twelve (29%) of the patients had detectable levels of IFN-gamma. Thus, circulating levels of IL-12 p40 and to a lesser extent those of IL-12 p70, are elevated in children with septic shock and purpura, and correlate with severity of disease and outcome.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Blood Glucose / analysis
  • C-Reactive Protein / analysis
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Interferon-gamma / blood
  • Interleukin-10 / blood
  • Interleukin-12 / blood*
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Male
  • Purpura / blood*
  • Severity of Illness Index
  • Shock, Septic / blood*
  • Tumor Necrosis Factor-alpha / analysis


  • Blood Glucose
  • Interleukin-6
  • Interleukin-8
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Interleukin-12
  • Interferon-gamma
  • C-Reactive Protein