Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3'-untranslated region of the prothrombin gene

Br J Haematol. 1997 Sep;98(4):907-9. doi: 10.1046/j.1365-2141.1997.3093130.x.


The odds ratio for the FII 20210G/A mutation in 504 patients with venous thromboembolism compared to controls was 2.0 (95% CI 1.0-4.0) and, for factor V Leiden, 5.8 (95% CI 3.3-10.3). 3/504 patients were heterozygous for both mutations. None of the patients had combined natural anticoagulant deficiency and the FII 20210G/A mutation. We conclude that the FII 20210G/A mutation is present in 2.6% of the population and the relative risk of venous thromboembolism in carriers is 2.0.

MeSH terms

  • Factor V / genetics
  • Heterozygote
  • Homozygote
  • Humans
  • Mutation*
  • Prothrombin / genetics*
  • Risk Factors
  • Thromboembolism / genetics*


  • factor V Leiden
  • Factor V
  • Prothrombin