Prolonged retinal arterio-venous circulation time by fluorescein but not by indocyanine green angiography in birdshot chorioretinopathy

Ocul Immunol Inflamm. 1997 Sep;5(3):203-6. doi: 10.3109/09273949709116895.


Purpose: To compare retinal arterio-venous circulation time by fluorescein (FA) and indocyanine green angiography (ICGA) in birdshot chorioretinopathy.

Methods: We analyzed prolonged retinal arterio-venous fluorescein transit time, a known feature in birdshot chorioretinopathy and correlated it with ICGA findings in four consecutive patients.

Results: Mean retinal arterio-venous fluorescein circulation time was 31.1 +/- 5.2 seconds, a transit time significantly longer than in a group of ten patients with sarcoidosis (9.45 +/- 3.36 sec., p < 0.0001) and in a group of three cases with Vogt-Koyanagi-Harada disease (7.0 +/- 1.1 sec., p < 0.0001).

Conclusion: Prolonged fluorescein arterio-venous transit time seems to be a characteristic feature of birdshot chorioretinopathy that does however not reflect the actual intravascular hemodynamic situation but diffuse blood-retinal barrier damage allowing exudation, slow gradual tissue impregnation and delayed venous reabsorption of small molecules like fluorescein.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angiography / methods
  • Blood Circulation Time
  • Chorioretinitis / physiopathology*
  • Coloring Agents
  • Female
  • Fluorescein Angiography
  • HLA-A Antigens / analysis
  • Humans
  • Indocyanine Green
  • Male
  • Middle Aged
  • Retinal Vessels / physiopathology*


  • Coloring Agents
  • HLA-A Antigens
  • HLA-A29 antigen
  • Indocyanine Green