The influence of dosage form on aspirin kinetics: implications for acute cardiovascular use

Curr Med Res Opin. 1997;13(10):547-53. doi: 10.1185/03007999709113328.


In this study, the pharmacokinetics of several formulations of aspirin were examined: soluble aspirin, mouth-dispersible aspirin, plain aspirin and enteric-coated aspirin granules. Blood samples were taken at frequent intervals for 24 hours after single dosing in 12 healthy volunteers and Tmax, Cmax and t1/2 measured. Cmax was significantly higher for soluble aspirin than for the other formulations and the t1/2 was shorter. The results show the rapid absorption of aspirin from a soluble formulation compared with that from plain aspirin or enteric-coated aspirin granules. Recommendations to treat patients suspected of having a heart attack as soon as possible with aspirin are now widely accepted and the present study would suggest that soluble aspirin should be the aspirin of choice in this situation.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aspirin / chemistry*
  • Aspirin / pharmacokinetics*
  • Aspirin / therapeutic use
  • Biological Availability
  • Chemistry, Pharmaceutical
  • Cross-Over Studies
  • Drug Monitoring
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Myocardial Infarction / drug therapy
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / pharmacokinetics*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Solubility
  • Tablets, Enteric-Coated
  • Time Factors


  • Platelet Aggregation Inhibitors
  • Tablets, Enteric-Coated
  • Aspirin