Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Oct;151(4):975-83.

Expression and Function of Endothelial Cell Alpha v Integrin Receptors in Wound-Induced Human Angiogenesis in Human skin/SCID Mice Chimeras

Affiliations
Free PMC article

Expression and Function of Endothelial Cell Alpha v Integrin Receptors in Wound-Induced Human Angiogenesis in Human skin/SCID Mice Chimeras

M Christofidou-Solomidou et al. Am J Pathol. .
Free PMC article

Abstract

Accumulating evidence indicates that endothelial cell integrins that bind to the matrix proteins associated with inflammation and wound healing are involved in the process of angiogenesis. The integrins containing the alpha v subunit appear to be particularly important. To study the involvement of these receptors in human angiogenesis, a model of wound-associated human angiogenesis was established in human skin transplanted onto severe combined immunodeficient (SCID) mice. Using this model, we studied the expression of several alpha v integrins and tested the hypothesis that blockage of the alpha v beta 3 integrin would inhibit human angiogenesis during human wound healing. These studies revealed that the alpha v beta 3, alpha v beta 5, and alpha v beta 6 integrins are up-regulated briefly during wound angiogenesis with different patterns of expression and that inhibition of the alpha v beta 3 integrin blocked new vessel formation during human wound healing.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

References

    1. J Biol Chem. 1987 Dec 25;262(36):17703-11 - PubMed
    1. J Immunol. 1997 May 15;158(10):4872-8 - PubMed
    1. J Clin Invest. 1989 Dec;84(6):1916-23 - PubMed
    1. J Natl Cancer Inst. 1990 Jan 3;82(1):4-6 - PubMed
    1. Cancer Res. 1990 Oct 15;50(20):6757-64 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback