Rationale and Clinical Status of Local Hyperthermia, Radiation, and Chemotherapy in Locally Advanced Malignancies

Anticancer Res. Jul-Aug 1997;17(4B):2895-7.


The combination of ionizing irradiation and local hyperthermia therapy has been demonstrated to be efficacious in a variety of localized neoplasms. One of the most consistent conclusions from this experience, however, is the finding that large tumor size is a significant negative prognosticator for attaining complete tumor regression. During the past decade investigators have begun to look at the possibility of adding chemotherapy to thermo-radiotherapy in order to improve the efficacy of treatment in patients with large tumors. This review article summarizes the recent clinical experience with such triple modality therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Combined Modality Therapy
  • Humans
  • Hyperthermia, Induced*
  • Neoplasms / therapy*


  • Antineoplastic Agents