Poisoning by sodium channel blocking agents

Crit Care Clin. 1997 Oct;13(4):829-48. doi: 10.1016/s0749-0704(05)70371-7.


Poisoning by drugs that block voltage-gated sodium channels produces intraventricular conduction defects, myocardial depression, bradycardia, and ventricular arrhythmias. Human and animal reports suggest that hypertonic sodium bicarbonate may be effective therapy for numerous agents possessing sodium channel blocking properties, including cocaine, quinidine, procainamide, flecainide, mexiletine, bupivacaine, and others.

Publication types

  • Review

MeSH terms

  • Action Potentials
  • Drug-Related Side Effects and Adverse Reactions
  • Heart / drug effects
  • Heart Diseases / chemically induced*
  • Heart Diseases / drug therapy
  • Humans
  • Poisoning / complications
  • Sodium Bicarbonate / therapeutic use
  • Sodium Channel Blockers*
  • Sodium Channels / physiology


  • Sodium Channel Blockers
  • Sodium Channels
  • Sodium Bicarbonate