CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

Curr Opin Cell Biol. 1997 Oct;9(5):616-26. doi: 10.1016/s0955-0674(97)80114-7.


The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell-cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carcinoembryonic Antigen / physiology*
  • Cell Adhesion Molecules / physiology*
  • Humans
  • Molecular Sequence Data
  • Signal Transduction / physiology*


  • Carcinoembryonic Antigen
  • Cell Adhesion Molecules