Interendothelial junctions: structure, signalling and functional roles

Curr Opin Cell Biol. 1997 Oct;9(5):674-82. doi: 10.1016/s0955-0674(97)80121-4.


Endothelial cell-cell adhesive junctions are formed by transmembrane adhesive proteins linked to a complex cytoskeletal network. These structures are important not only for maintaining adhesion between endothelial cells and, as a consequence, for the control of vascular permeability, but also for intracellular signalling properties. The establishment of intercellular junctions might affect the endothelial functional phenotype by the downregulation or upregulation of endothelial-specific activities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Endothelium / physiology*
  • Endothelium / ultrastructure
  • Humans
  • Intercellular Junctions / physiology*
  • Signal Transduction / physiology