Integrin signaling: specificity and control of cell survival and cell cycle progression

Curr Opin Cell Biol. 1997 Oct;9(5):691-700. doi: 10.1016/s0955-0674(97)80123-8.

Abstract

Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Cell Survival / physiology
  • Epithelial Cells / physiology
  • Fibroblasts / physiology
  • Integrins / physiology*
  • Signal Transduction / physiology*

Substances

  • Integrins