Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

Curr Opin Cell Biol. 1997 Oct;9(5):714-24. doi: 10.1016/s0955-0674(97)80126-3.


Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cell Movement / physiology*
  • Humans
  • Integrins / physiology*
  • Plasminogen Activators / physiology*
  • Receptors, Cell Surface / physiology
  • Receptors, Urokinase Plasminogen Activator


  • Integrins
  • PLAUR protein, human
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • Plasminogen Activators