Different course of reactive arthritis in two HLA-B27 positive brothers with fatal outcome in one

J Rheumatol. 1997 Oct;24(10):2047-50.


During an outbreak of Yersinia pseudotuberculosis III, one of two HLA-B27 positive brothers developed reactive arthritis (ReA), mild at first, but later severely destructive and ultimately fatal. The reactivation of ReA was possibly triggered by an oral polio vaccine. The cause of death was severe secondary amyloidosis. The other brother was exposed to the same Y. pseudotuberculosis strain but did not develop any disease during or after the outbreak. However, he later developed ReA due to a Salmonella infection, with a benign course.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Amyloidosis / etiology
  • Arthritis, Reactive / etiology*
  • Arthritis, Reactive / genetics
  • Fatal Outcome
  • HLA-B27 Antigen / genetics*
  • Humans
  • Male
  • Poliovirus Vaccine, Oral / adverse effects
  • Prohibitins
  • Radiography
  • Spondylitis, Ankylosing / diagnostic imaging
  • Spondylitis, Ankylosing / etiology
  • Wrist / diagnostic imaging
  • Yersinia pseudotuberculosis Infections / complications*


  • HLA-B27 Antigen
  • PHB2 protein, human
  • Poliovirus Vaccine, Oral
  • Prohibitins