Changes in the alpha 2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

Neuroreport. 1997 Sep 29;8(14):3119-22. doi: 10.1097/00001756-199709290-00022.


We examined changes in expression of genes coding for alpha 2-AR subtypes in the dorsal root ganglion (DRG) in a rat model (spinal nerve ligation) or neuropathic pain. The present study demonstrates that the majority of DRG neurons express alpha 2C-AR mRNA and a small proportion of neurons express alpha 2A-AR mRNA, while few neurons express alpha 2B-AR mRNA in non-operated animals. In addition, alpha 2C- and alpha 2A mRNA levels in the DRG showed a significant decrease and increase, respectively in ligated animals. These findings suggest that alpha 2A- and alpha 2C-ARs in the DRG may play an important role in generating sympathetically maintained neuropathic pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Ganglia, Spinal / metabolism*
  • Gene Expression
  • Genetic Code
  • In Situ Hybridization
  • Neuralgia / metabolism*
  • Polymerase Chain Reaction / methods
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Adrenergic, alpha-2 / genetics*
  • Transcription, Genetic


  • Receptors, Adrenergic, alpha-2