Interneuron Migration From Basal Forebrain to Neocortex: Dependence on Dlx Genes

Science. 1997 Oct 17;278(5337):474-6. doi: 10.1126/science.278.5337.474.

Abstract

Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calbindins
  • Cell Movement
  • Corpus Striatum / cytology*
  • Corpus Striatum / embryology
  • Corpus Striatum / metabolism
  • Culture Techniques
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Genes, Homeobox*
  • Glutamate Decarboxylase / metabolism
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / physiology
  • Interneurons / chemistry
  • Interneurons / physiology*
  • Mice
  • Mutation
  • Neocortex / cytology*
  • Neocortex / embryology
  • Neocortex / metabolism
  • S100 Calcium Binding Protein G / analysis
  • Telencephalon / cytology*
  • Telencephalon / embryology
  • Telencephalon / metabolism
  • Transcription Factors
  • gamma-Aminobutyric Acid / analysis

Substances

  • Calbindins
  • DNA-Binding Proteins
  • Distal-less homeobox proteins
  • Homeodomain Proteins
  • S100 Calcium Binding Protein G
  • Tes protein, mouse
  • Transcription Factors
  • gamma-Aminobutyric Acid
  • Glutamate Decarboxylase