The effect of methylphenidate on the cognitive and personality functioning of ADHD children

Isr J Psychiatry Relat Sci. 1997;34(3):200-9.


Twenty Israeli children diagnosed as having Attention Deficit Hyperactivity Disorder (ADHD) participated in the study. The study used a double-blind, cross-over, placebo-control design, in which each child received a three-week treatment of methylphenidate (MPH), and a three-week treatment with a placebo. Their teachers completed the Conners' Teacher Rating Scale (CTRS) along with ratings of other variables prior to the beginning of the study and during the two treatment periods. The subjects were tested on a specially designed battery of both cognitive and personality tests at the end of each treatment period. The results showed significant differences between ratings of children's behavior in pretest and subsequent placebo and MPH treatment periods. Comparison of the MPH and placebo treatment revealed no differences in any of the measures assessing cognitive ability and personality characteristics.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Central Nervous System Stimulants / pharmacology*
  • Central Nervous System Stimulants / therapeutic use
  • Child
  • Cognition / drug effects*
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Methylphenidate / pharmacology*
  • Methylphenidate / therapeutic use
  • Personality / drug effects*


  • Central Nervous System Stimulants
  • Methylphenidate