Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin

Nat Struct Biol. 1997 Oct;4(10):779-83. doi: 10.1038/nsb1097-779.

Abstract

Amaranthus caudatus agglutinin contains a novel arrangement of four beta-trefoil domains. The sugar-binding site provides specificity for the carcinoma-associated T-antigen disaccharide even when 'masked' by other sugars.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Viral, Tumor / chemistry*
  • Benzyl Compounds
  • Crystallography, X-Ray / methods
  • Dimerization
  • Disaccharides*
  • Edible Grain
  • Lectins / chemistry*
  • Models, Molecular
  • Plant Lectins
  • Protein Conformation*
  • Ribosome Inactivating Proteins
  • Ribosome Inactivating Proteins, Type 1
  • Seeds

Substances

  • Antigens, Viral, Tumor
  • Benzyl Compounds
  • Disaccharides
  • Lectins
  • Plant Lectins
  • Ribosome Inactivating Proteins, Type 1
  • amaranthin protein, Amaranthus
  • Ribosome Inactivating Proteins