Serum levels of soluble tumor-necrosis-factor receptors in patients with benign and malignant HPV-associated anogenital lesions

Int J Cancer. 1997 Sep 26;73(1):16-9. doi: 10.1002/(sici)1097-0215(19970926)73:1<16::aid-ijc3>;2-4.


The levels of type-I and type-II soluble TNF-alpha receptors (sTNF-Rs) were evaluated in sera from patients with various human-papillomavirus-(HPV)-associated benign and malignant anogenital lesions using specific enzyme-linked immunobiological assays. In patients with benign HPV6/11-associated condylomata acuminata, the levels of sTNF-RI were significantly increased, while sTNF-RII were in normal range. Both types of sTNF-Rs were in normal range in patients with benign HPV16-associated grade-I/II and grade-III cervical intra-epithelial neoplasia. However, their levels were significantly increased in patients with HPV16/18-associated squamous cervical cancer and anogenital Bowen's carcinoma. Sera from patients with condylomata acuminata and anogenital carcinomas displayed significantly increased TNF-alpha-inhibitory activity, as revealed by L929 cell-cytotoxicity assay. Increased serum TNF-alpha-inhibitory activity correlated with higher levels of sTNF-Rs. Furthermore, this inhibitory activity could be specifically abrogated by htr9 and utr1 monoclonal antibodies recognizing TNF-RI and TNF-RII respectively. Our results strongly suggest that serum sTNF-Rs may protect tumor cells from cytotoxic/cytostatic effects of locally released TNF-alpha, and that elevated levels of circulating sTNF-Rs may facilitate the growth of HPV-associated anogenital lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bowen's Disease / blood*
  • Carcinoma, Squamous Cell / blood*
  • Cervical Intraepithelial Neoplasia / blood*
  • Condylomata Acuminata / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Papillomaviridae*
  • Papillomavirus Infections / blood*
  • Receptors, Tumor Necrosis Factor / blood*
  • Tumor Virus Infections / blood*
  • Uterine Cervical Neoplasms / blood*


  • Receptors, Tumor Necrosis Factor