Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole

East Afr Med J. 1997 May;74(5):283-4.


Two hundred and fifteen patients with chloroquine-resistant malaria were randomised into three groups. The first group of 82 patients were given pyrimethamine and berberine (berberine group), the second group of 64 patients, pyrimethamine and tetracycline (tetracycline group) and the third group of 69 patients were given pyrimethamine and cotrimoxazole (cotrimoxazole group). In the berberine group, the clearance, rate of asexual parasitaemia was 74.4% after treatment, while in the tetracycline group it was 67.2% and in the cotrimoxazole group 47.8%. These results indicate that berberine is more effective in clearing the parasite than both tetracycline and cotrimoxazole, and that the combination of pyrimethamine and berberine gives the best results for chloroquine resistant malaria.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Antimalarials / therapeutic use*
  • Berberine / therapeutic use*
  • Child
  • Child, Preschool
  • Chloroquine*
  • Drug Resistance
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infant
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / parasitology
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyrimethamine / therapeutic use*
  • Tetracycline / therapeutic use*
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*


  • Anti-Bacterial Agents
  • Antimalarials
  • Berberine
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Chloroquine
  • Tetracycline
  • Pyrimethamine